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International Immunology 2008 20(7):NP; doi:10.1093/intimm/dxn067
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© The Japanese Society for Immunology. 2008. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

IN THIS ISSUE

The first 10% of the full text of this article appears below.


   Matrix metalloproteinases and NK cell cytotoxicity
 
Ligation of receptors such as NKG2D on NK cells to ligands on tumour cells can trigger cytotoxicity. In this issue, Mami-Chouaib and colleagues (p. 801) show that matrix metalloproteinases (MMPs) can enable lung cancer cell lines to shed the ligands and escape killing. Using MMP inhibitors, perhaps in combination with IL-15, might circumvent this evasion mechanism.


   Bam32 activates Erk in T cells
 
B lymphocyte adapter molecule of 32 kD (Bam32) is known to be involved in BCR-mediated signalling. Here, Samelson and colleagues . . . [Full Text of this Article]


   Levels of CD45 isoforms and T cell signalling
 

   Activation of {gamma}{delta} cells by a probiotic
 

   The phenotype of alloreactive killer cells
 

   Two pathways for Th1 generation by mycobacteria
 

   Regulatory T cells in SLE
 

   NKT cells break CTL tolerance to HBV
 

   Constitutive TLR-mediated B cell activation in lupus
 

   Oral antigens reduce numbers of T cells
 

   Signalling pathways in keratinocyte antiviral responses
 

   S1P1 agonism impairs dendritic cell migration
 

   ICAT is important for thymocyte development
 

   MHC-restricted suppression by CD8+CD122+ Tregs
 

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